Article

Sustained experimental activation of FGF8/ERK in the developing chicken spinal cord reproducibly models early events in ERK-mediated tumorigenesis

2021-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Most human cancers demonstrate activated MAPK/ERK pathway signaling as a key tumor initiation step, but the immediate steps of further oncogenic progression are poorly understood due to a lack of appropriate models. Spinal cord differentiation follows caudal elongation in vertebrate embryos; both processes are regulated by a FGF8 gradient highest in neuromesodermal progenitors (NMP), where kinas...

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Literature Corpus work: e1220557-9bb0-50ac-9494-c383a3d6bb31
DOI: 10.1101/2021.06.10.447891

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