Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas.

doi:10.1038/s41392-022-00890-7

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Article

Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas.

Signal transduction and targeted therapy - 11 Mar 2022

Wang Yan-Xia, Wu Haibo, Ren Yong, Lv Shengqing, Ji Chengdong, Xiang Dongfang, Zhang Mengsi, Lu Huimin, Fu Wenjuan, Liu Qing, Yan Zexuan, Ma Qinghua, Miao Jingya, Cai Ruili, Lan Xi, Wu Bin, Wang Wenying, Liu Yinhua, Wang Dai-Zhong, Cao Mianfu, He Zhicheng, Shi Yu, Ping Yifang, Yao Xiaohong, Zhang Xia, Zhang Peng, Wang Ji Ming, Wang Yan, Cui Youhong, Bian Xiu-Wu

Abstract excerpt

Medulloblastoma (MB) is one of the most common childhood malignant brain tumors (WHO grade IV), traditionally divided into WNT, SHH, Group 3, and Group 4 subgroups based on the transcription profiles, somatic DNA alterations, and clinical outcomes. Unlike WNT and SHH subgroup MBs, Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options. The recently...

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PMID: 35273141
DOI: 10.1038/s41392-022-00890-7
PMCID: PMC8913686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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