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Functional Genomics Identifies Drivers of Medulloblastoma Dissemination

9 Aug 2012

Abstract excerpt

Medulloblastomas are malignant brain tumors that arise in the cerebellum in children and disseminate via the cerebrospinal fluid to the leptomeningeal spaces of the brain and spinal cord. Challenged by the poor prognosis for patients with metastatic dissemination, pediatric oncologists have developed aggressive treatment protocols, combining surgery, craniospinal radiation, and high-dose chemotherapy, that often...

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PMID: 22875024
DOI: 10.1158/0008-5472.can-12-1629

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