Article

N-terminal mutant Huntingtin deposition correlates with CAG repeat length and disease onset, but not neuronal loss in Huntington’s disease

2022-05-04

Abstract excerpt

Huntington’s disease (HD) is caused by a CAG repeat expansion mutation in the gene encoding the huntingtin (Htt) protein, with mutant Htt protein subsequently forming aggregates within the brain. Mutant Htt is a current target for novel therapeutic strategies for HD, however, the lack of translation from preclinical research to disease-modifying treatments highlights the need to improve our understanding of the ro...

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Literature Corpus work: 6fdf0406-32bc-50c9-840e-557e11727fef
DOI: 10.1101/2022.05.03.490349

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