Article
N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease.
Neurobiology of disease - 1 Nov 2022
Layburn Florence E, Tan Adelie Y S, Mehrabi Nasim F, Curtis Maurice A, Tippett Lynette J, Turner Clinton P, Riguet Nathan, Aeschbach Lorène, Lashuel Hilal A, Dragunow Mike, Faull Richard L M, Singh-Bains Malvindar K
Abstract excerpt
Huntington's disease (HD) is caused by a CAG repeat expansion mutation in the gene encoding the huntingtin (Htt) protein, with mutant Htt protein subsequently forming aggregates within the brain. Mutant Htt is a current target for novel therapeutic strategies for HD, however, the lack of translation from preclinical research to disease-modifying treatments highlights the need to improve our understanding of the...
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