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Analysis of mutant and total huntingtin expression in Huntington's disease murine models.

Scientific reports - 17 Dec 2020

Fodale Valentina, Pintauro Roberta, Daldin Manuel, Altobelli Roberta, Spiezia Maria Carolina, Bisbocci Monica, Macdonald Douglas, Bresciani Alberto

Abstract excerpt

Huntington's disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms that drive pathology. Expression of the mutant form of HTT is a key aspect of diseased tissues, and the most promising therapeutic approaches aim to lower expanded HTT levels....

Topics

Animals
Biomarkers
Brain
Disease Models, Animal
Fibroblasts
Gene Expression
Gene Knock-In Techniques
Humans
Huntingtin Protein
Huntington Disease
Immunoassay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Mice

Mutation

Rats

Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 33335120
DOI: 10.1038/s41598-020-78790-5
PMCID: PMC7746729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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