Article

Mutant HTT protein decreases with CAG repeat expansion: implications for therapeutics and bioassays

2024-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease is an inherited neurodegenerative disorder caused by a CAG repeat expansion that encodes a polyglutamine tract in the HTT protein. The mutant CAG repeat is unstable and expands in specific brain cells and peripheral tissues throughout life. Genes involved in the DNA mismatch repair pathways, known to act on expansion, have been identified as genetics modifiers, therefore, it...

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Literature Corpus work: 58900146-09ed-5282-969b-c947f5c95e61
DOI: 10.1101/2024.06.11.598410

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