Article

Enhancing the detection of HTT1a with neoepitope antibodies in mouse models of Huntington’s disease

2026-03-03

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease is an inherited neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the Huntingtin ( HTT ) gene, encoding an expanded polyglutamine tract in the huntingtin (HTT) protein. The pathogenic CAG repeat of HTT is unstable and undergoes progressive somatic expansion in specific brain cells and peripheral tissues throughout life. Genes involved in DNA mismatch...

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Literature Corpus work: 35b579cf-c41b-545c-b0f7-0eac59babd2e
DOI: 10.64898/2026.03.01.708805

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