Article

Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington’s disease human cerebral cortex

2025-02-03

Abstract excerpt

Huntington’s disease (HD) is a hereditary neurodegenerative condition caused by a CAG repeat expansion mutation in the gene encoding the huntingtin (Htt) protein. The accumulation of Htt inclusion bodies is a pathological hallmark of HD and a common target for therapeutic strategies. However, the limited efficacy of treatments targeting the Htt protein highlights the need for a better understanding of the role of...

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Literature Corpus work: 845be9a4-3019-5fc6-9eaa-4aeb0bfd5d6b
DOI: 10.1101/2025.02.03.636327

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