Article

Localization of Mutant Huntingtin with HTT Exon1 P90 C-terminal Neoepitope Antibodies in Relation to Regional and Neuronal Vulnerability in Forebrain in Q175 Mice and Human Huntington’s Disease

2025-08-09

Abstract excerpt

<h4>Background</h4> Recent evidence suggests that accumulation of mutant exon 1 protein (HTT1a) may be critical to HD pathogenesis, but the relation of this to differential regional and cellular vulnerability in HD is unknown. <h4>Objective</h4> We assessed the contribution of the accumulation of the mutant huntingtin HTT1a to the regional and cellular variation in HD brain pathology by determining if more vulne...

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Literature Corpus work: 5795f99e-330b-55b9-b144-909bc0185b00
DOI: 10.1101/2025.08.06.668984

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Localization of Mutant Huntingtin with HTT Exon1 P90 C-terminal Neoepitope Antibodies in Relation to Regional and Neuronal Vulnerability in Forebrain in Q175 Mice and Human Huntington’s DiseaseDOI 10.1101/2025.08.06.668984Read

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