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Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry

18 May 2024

Abstract excerpt

Antibodies are essential research tools whose performance directly impacts research conclusions and reproducibility. Owing to its central role in Alzheimer's disease and other dementias, hundreds of distinct antibody clones have been developed against the microtubule-associated protein Tau and its multiple proteoforms. Despite this breadth of offer, limited understanding of their performance and poor antibody...

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PMID: 38761203
DOI: 10.1007/s00401-024-02729-7

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