Article
Phosphorylation of Argonaute proteins: regulating gene regulators.
The Biochemical journal - 1 Aug 2008
Rüdel Sabine, Meister Gunter
Abstract excerpt
Members of the Ago (Argonaute) protein family are the mediators of small RNA-guided gene-silencing pathways including RNAi (RNA interference), translational regulation by miRNAs (microRNAs) and transcriptional silencing. Recent findings by Zeng et al. in this issue of the Biochemical Journal demonstrate that Ago proteins are post-translationally modified by phosphorylation of Ser(387). Mutating Ser(387) to...
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