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Phosphorylation by CK2 increases the SUMO-dependent activity of Cytomegalovirus transactivator IE2

2019-05-30

Abstract excerpt

Viral factors manipulate the host post-translational modification (PTM) machinery for replication. Distinctly, phosphorylation and SUMOylation can regulate the activity of human cytomegalovirus (HCMV) protein IE2. However, the molecular mechanism of this process is unknown. Taking a structural, biochemical and cellular approach, we uncover a cross-talk of phosphorylation and SUMOylation exploited by IE2. A scan fo...

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Literature Corpus work
2ba15d0f-929e-513f-83ee-a1cd1c02305b
DOI
10.1101/655282
Open publication

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Phosphorylation by CK2 increases the SUMO-dependent activity of Cytomegalovirus transactivator IE2DOI 10.1101/655282
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