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Article

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.

The Biochemical journal - 1 Aug 2008

Zeng Yan, Sankala Heidi, Zhang Xiaoxiao, Graves Paul R

Abstract excerpt

Ago (Argonaute) proteins are essential effectors of RNA-mediated gene silencing. To explore potential regulatory mechanisms for Ago proteins, we examined the phosphorylation of human Ago2. We identified serine-387 as the major Ago2 phosphorylation site in vivo. Phosphorylation of Ago2 at serine-387 was significantly induced by treatment with sodium arsenite or anisomycin, and arsenite-induced phosphorylation was...

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Identifiers

PMID: 18476811
DOI: 10.1042/BJ20080599

Genes

MAPKAPK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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