Article

Soluble VEGF isoforms are essential for establishingepiphyseal vascularization and regulating chondrocyte development and survival

2004-01-06

Abstract excerpt

VEGF is crucial for metaphyseal bone vascularization. In contrast, the angiogenic factors required for vascularization of epiphyseal cartilage are unknown, although this represents a developmentally and clinically important aspect of bone growth. The VEGF gene is alternatively transcribed into VEGF 120 , VEGF 164 , and VEGF 188 isoforms that differ in matrix association and receptor binding. Their role in bone dev...

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Literature Corpus work: 6fb6207e-d877-5184-8b68-333583aa0a8a
DOI: 10.1172/jci200419383

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