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Article

Inactivation of Vhl in osteochondral progenitor cells causes high bone mass phenotype and protects against age-related bone loss in adult mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2014

Weng Tujun, Xie Yangli, Huang Junlan, Luo Fengtao, Yi Lingxian, He Qifen, Chen Di, Chen Lin

Abstract excerpt

Previous studies have shown that disruption of von Hippel-Lindau gene (Vhl) coincides with activation of hypoxia-inducible factor α (HIFα) signaling in bone cells and plays an important role in bone development, homeostasis, and regeneration. It is known that activation of HIF1α signaling in mature osteoblasts is central to the coupling between angiogenesis and bone formation. However, the precise mechanisms...

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Identifiers

PMID: 23999831
DOI: 10.1002/jbmr.2087
PMCID: PMC4111233

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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