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Regulation of the Bone Vascular Network is Sexually Dimorphic

3 Jul 2019

Abstract excerpt

Osteoblast (OB) lineage cells are an important source of vascular endothelial growth factor (VEGF), which is critical for bone growth and repair. During bone development, pubertal differences in males and females exist, but little is known about whether VEGF signaling contributes to skeletal sexual dimorphism. We have found that in mice, conditional disruption of VEGF in osteocalcin-expressing cells (OcnVEGFKO)...

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PMID: 31269275
DOI: 10.1002/jbmr.3825

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