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Article

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival.

Genes & development - 1 Nov 2001

Schipani E, Ryan H E, Didrickson S, Kobayashi T, Knight M, Johnson R S

Abstract excerpt

Breakdown or absence of vascular oxygen delivery is a hallmark of many common human diseases, including cancer, myocardial infarction, and stroke. The chief mediator of hypoxic response in mammalian tissues is the transcription factor hypoxia-inducible factor 1 (HIF-1), and its oxygen-sensitive component HIF-1alpha. A key question surrounding HIF-1alpha and the hypoxic response is the role of this transcription...

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Identifiers

PMID: 11691837
DOI: 10.1101/gad.934301
PMCID: PMC312800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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