Article
Unique vascular phenotypes following over-expression of individual VEGFA isoforms from the developing lens.
Angiogenesis - 1 Jan 2006
Mitchell Christopher A, Rutland Catrin S, Walker Michael, Nasir Muneeb, Foss Alexander J E, Stewart Christine, Gerhardt Holger, Konerding Moritz A, Risau Werner, Drexler Hannes C A
Abstract excerpt
Formation of a correctly organised vasculature and subsequently embryonic survival is critically dependent on the dosage and site-specific expression of VEGF. Murine VEGF exists in three common isoforms (viz. 120, 164 and 188 amino acids) having different organ specific distribution levels. Gene knock-in studies show that expression of any of the individual isoforms of VEGF extends survival until birth, although...
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