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Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development

15 May 2015

Abstract excerpt

Vascular endothelial growth factor A (Vegfa) has important roles in endochondral bone formation. Osteoblast precursors, endothelial cells and osteoclasts migrate from perichondrium into primary ossification centers of cartilage templates of future bones in response to Vegfa secreted by (pre)hypertrophic chondrocytes. Perichondrial osteolineage cells also produce Vegfa, but its function is not well understood. By...

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PMID: 25977369
DOI: 10.1242/dev.117952

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