Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival.

The Journal of clinical investigation - 1 Jan 2004

Maes Christa, Stockmans Ingrid, Moermans Karen, Van Looveren Riet, Smets Nico, Carmeliet Peter, Bouillon Roger, Carmeliet Geert

Abstract excerpt

VEGF is crucial for metaphyseal bone vascularization. In contrast, the angiogenic factors required for vascularization of epiphyseal cartilage are unknown, although this represents a developmentally and clinically important aspect of bone growth. The VEGF gene is alternatively transcribed into VE...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiography
Share to Bone Development
Share to Bromodeoxyuridine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cartilage

Share to In Situ Nick-End Labeling

Share to Receptors, Vascular Endothelial Growth Factor

Share to Ribonucleoproteins

Share to Xenopus Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 14722611
DOI: 10.1172/JCI19383
PMCID: PMC312596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14722611-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival.PMID 14722611Read ↗

Soluble VEGF isoforms are essential for establishingepiphyseal vascularization and regulating chondrocyte development and survivalSemantic proximity Read ↗

Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state.Semantic proximity Read ↗

Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone developmentSemantic proximity Read ↗

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival.Semantic proximity Read ↗

Conditional deletion of HDAC4 from collagen type 2α1-expressing cells increases angiogenesis in vivo.Semantic proximity Read ↗

Regulation of the Bone Vascular Network is Sexually DimorphicSemantic proximity Read ↗

Unique vascular phenotypes following over-expression of individual VEGFA isoforms from the developing lens.Semantic proximity Read ↗

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene.Semantic proximity Read ↗

Inactivation of Vhl in osteochondral progenitor cells causes high bone mass phenotype and protects against age-related bone loss in adult mice.Semantic proximity Read ↗

Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development.Semantic proximity Read ↗

Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation.Semantic proximity Read ↗

An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillarisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.