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Article

The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.

International journal of molecular sciences - 31 Aug 2017

Nepomuceno Thales C, De Gregoriis Giuliana, de Oliveira Francisco M Bastos, Suarez-Kurtz Guilherme, Monteiro Alvaro N, Carvalho Marcelo A

Abstract excerpt

The deoxyribonucleic acid (DNA) damage response (DDR) is a major feature in the maintenance of genome integrity and in the suppression of tumorigenesis. PALB2 (Partner and Localizer of Breast Cancer 2 (BRCA2)) plays an important role in maintaining genome integrity through its role in the Fanconi anemia (FA) and homologous recombination (HR) DNA repair pathways. Since its identification as a BRCA2 interacting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28858227
DOI: 10.3390/ijms18091886
PMCID: PMC5618535

Genes

PALB2
BRCA2
ATM
ATR
BRCA1
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.PMID 28858227Read ↗

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RAD51 and PALB2 in precision oncology: Clinical implications for HRD associated breast and ovarian cancers (Review)Semantic proximity Read ↗

BRCA1-Dependent and Independent Recruitment of PALB2–BRCA2–RAD51 in the DNA Damage Response and CancerSemantic proximity Read ↗

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PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.Semantic proximity Read ↗

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Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.Semantic proximity Read ↗

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