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Article

Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.

PLoS genetics - 1 Dec 2011

Siaud Nicolas, Barbera Maria A, Egashira Akinori, Lam Isabel, Christ Nicole, Schlacher Katharina, Xia Bing, Jasin Maria

Abstract excerpt

The breast cancer suppressor BRCA2 is essential for the maintenance of genomic integrity in mammalian cells through its role in DNA repair by homologous recombination (HR). Human BRCA2 is 3,418 amino acids and is comprised of multiple domains that interact with the RAD51 recombinase and other proteins as well as with DNA. To gain insight into the cellular function of BRCA2 in HR, we created fusions consisting of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22194698
DOI: 10.1371/journal.pgen.1002409
PMCID: PMC3240595

Genes

BRCA2
PALB2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.PMID 22194698Read ↗

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RAD51 and PALB2 in precision oncology: Clinical implications for HRD associated breast and ovarian cancers (Review)Semantic proximity Read ↗

Mechanisms underlying genome maintenance and tumour suppression by BRCA2Semantic proximity Read ↗

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.Semantic proximity Read ↗

Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivitySemantic proximity Read ↗

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