Article

Structural analysis of genetic variants of the human tumor suppressor Palb2 coiled-coil domain

2024-03-19

Abstract excerpt

Homologous recombination (HR) is an obligate pathway to repair DNA lesions and maintain genome integrity. The tumor suppressor Palb2 is an integral part of the HR pathway that functionally connects BRCA proteins at the site of DNA damage. The N-terminal coiled-coil domain in Palb2 switches from an inactive to an active complex during HR. In the inactive form, Palb2 forms homodimers, and during HR, it assumes the a...

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Literature Corpus work: 09326fc5-d2d3-5bdd-a4e4-87508ed61032
DOI: 10.1101/2024.03.19.585655

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