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Article

Guardians of the Genome: BRCA2 and Its Partners.

Genes - 10 Aug 2021

Le Hang Phuong, Heyer Wolf-Dietrich, Liu Jie

Abstract excerpt

The tumor suppressor BRCA2 functions as a central caretaker of genome stability, and individuals who carry BRCA2 mutations are predisposed to breast, ovarian, and other cancers. Recent research advanced our mechanistic understanding of BRCA2 and its various interaction partners in DNA repair, DNA replication support, and DNA double-strand break repair pathway choice. In this review, we discuss the biochemical and...

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Share to BRCA2 Protein
Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Homologous Recombination

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Identifiers

PMID: 34440403
DOI: 10.3390/genes12081229
PMCID: PMC8394001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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