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Article

PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

Molecular cancer research : MCR - 1 Jul 2009

Zhang Fan, Fan Qiang, Ren Keqin, Andreassen Paul R

Abstract excerpt

BRCA1 and BRCA2 are prominently associated with inherited breast and ovarian cancer. The encoded proteins function in DNA damage responses, but no functional link between BRCA1 and BRCA2 has been established. We show here that PALB2 physically and functionally connects BRCA1 and BRCA2 into a DNA damage response network that also includes the RAD51 recombinase. PALB2 directly binds BRCA1, as determined with...

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Share to Apoptosis Regulatory Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group N Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 19584259
DOI: 10.1158/1541-7786.MCR-09-0123
PMCID: PMC4928587

Genes

PALB2
BRCA1
BRCA2
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.PMID 19584259Read ↗

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Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.Semantic proximity Read ↗

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RAD51 and PALB2 in precision oncology: Clinical implications for HRD associated breast and ovarian cancers (Review)Semantic proximity Read ↗

PALB2/FANCN: recombining cancer and Fanconi anemia.Semantic proximity Read ↗

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.Semantic proximity Read ↗

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PALB2 links BRCA1 and BRCA2 in the DNA-damage response.Semantic proximity Read ↗

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