Article

Novel strand exchange activity of the human PALB2 DNA Binding Domain and its critical role for DNA repair in cells

2018-12-13

Abstract excerpt

Breast cancer associated proteins 1 and 2 (BRCA1, -2) and partner and localizer of BRCA2 (PALB2) protein are tumor suppressors linked to a spectrum of malignancies, including breast cancer and Fanconi anemia. They stimulate RAD51 recombinase during homology-directed repair (HDR). Along with being a hub for a protein interaction network, PALB2 interacts with DNA. The mechanism of PALB2 DNA binding and its function...

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Literature Corpus work: f11f3f15-37b7-5029-baa2-25a68f4cd76f
DOI: 10.1101/495192

Open publication

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