Article
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.
Molecular cell - 23 Jun 2006
Xia Bing, Sheng Qing, Nakanishi Koji, Ohashi Akihiro, Wu Jianmin, Christ Nicole, Liu Xinggang, Jasin Maria, Couch Fergus J, Livingston David M
Abstract excerpt
BRCA2 mutations predispose carriers to breast and ovarian cancer and can also cause other cancers and Fanconi anemia. BRCA2 acts as a "caretaker" of genome integrity by enabling homologous recombination (HR)-based, error-free DNA double-strand break repair (DSBR) and intra-S phase DNA damage checkpoint control. Described here is the identification of PALB2, a BRCA2 binding protein. PALB2 colocalizes with BRCA2 in...
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