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Article

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.

Molecular cell - 3 Nov 2016

Grüner Stefan, Peter Daniel, Weber Ramona, Wohlbold Lara, Chung Min-Yi, Weichenrieder Oliver, Valkov Eugene, Igreja Cátia, Izaurralde Elisa

Abstract excerpt

Eukaryotic initiation factor 4G (eIF4G) plays a central role in translation initiation through its interactions with the cap-binding protein eIF4E. This interaction is a major drug target for repressing translation and is naturally regulated by 4E-binding proteins (4E-BPs). 4E-BPs and eIF4G compete for binding to the eIF4E dorsal surface via a shared canonical 4E-binding motif, but also contain auxiliary...

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Share to Crystallography, X-Ray
Share to Eukaryotic Initiation Factor-4E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptide Chain Initiation, Translational

Share to Protein Conformation, alpha-Helical

Share to Protein Conformation, beta-Strand

Share to Protein Interaction Domains and Motifs

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Source

Identifiers

PMID: 27773676
DOI: 10.1016/j.molcel.2016.09.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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