Article
Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex.
Nucleic acids research - 1 Sept 2014
Saini Adesh K, Nanda Jagpreet S, Martin-Marcos Pilar, Dong Jinsheng, Zhang Fan, Bhardwaj Monika, Lorsch Jon R, Hinnebusch Alan G
Abstract excerpt
eIF5 is the GTPase activating protein (GAP) for the eIF2 · GTP · Met-tRNAi (Met) ternary complex with a critical role in initiation codon selection. Previous work suggested that the eIF5 mutation G31R/SUI5 elevates initiation at UUG codons by increasing GAP function. Subsequent work implicated eIF5 in rearrangement of the preinitiation complex (PIC) from an open, scanning conformation to a closed state at AUG...
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