Article

Scalable <i>in vivo</i> cardiac functional genomics with compressed AAV-Perturb-seq reveals a common mitochondrial response to perturbation

2026-06-05

Abstract excerpt

<h4>SUMMARY</h4> Efficient identification of new targets to treat human disease requires a scalable way to link genotype to phenotype directly in the target organ. Pooled CRISPR screening with single-cell RNA sequencing as a readout (Perturb-seq) has emerged as a method for functional genomics but is typically applied in vitro and is limited in scale. Here, we combine in vivo Perturb-seq via adeno-associated vi...

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Literature Corpus work: 6faf1b1a-7486-554d-b002-7ed61d734c58
DOI: 10.64898/2026.06.01.729445

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