Article

CRISPRi Gene Modulation and All-Optical Electrophysiology in Post-Differentiated Human iPSC-Cardiomyocytes

2023-05-09

Abstract excerpt

<h4>ABSTRACT</h4> Uncovering gene-phenotype relationships can be enabled by precise gene modulation in human induced pluripotent stem-cell-derived cardiomyocytes (iPSC-CMs) and follow up phenotyping using scalable all- optical electrophysiology platforms. Such efforts towards human functional genomics can be aided by recent CRISPR-derived technologies for reversible gene inhibition or activation (CRISPRi/a). We s...

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Literature Corpus work: e637ec37-39d5-586c-ba4f-6abf6c204147
DOI: 10.1101/2023.05.07.539756

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