Article

Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing

2024-12-04

Abstract excerpt

The ability to efficiently make precise genome edits in somatic tissues will have profound implications for gene therapy and basic science. CRISPR/Cas9 mediated homology-directed repair (HDR) is one approach that is commonly used to achieve precise and efficient editing in cultured cells. Previously, we developed a platform capable of delivering CRISPR/ Cas 9 gRNAs and donor templates via a deno- a ssociated v...

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Literature Corpus work: 9c25ade4-a3c4-5e4c-ad3a-8afdcc82cdd7
DOI: 10.1101/2024.12.03.626493

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