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A combined human <i>in silico</i> and CRISPR/Cas9-mediated <i>in vivo</i> zebrafish based approach for supporting gene target validation in early drug discovery

2021-09-14

Abstract excerpt

The clinical heterogeneity of heart failure has challenged our understanding of the underlying genetic mechanisms of this disease. In this respect, large-scale patient DNA sequencing studies have become an invaluable strategy for identifying potential genetic contributing factors. The complex aetiology of heart failure, however, also means that in vivo models are vital to understand the links between genetic pert...

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Literature Corpus work
3951f5dc-0c77-5cb8-87f3-33703f5bc4d5
DOI
10.1101/2021.09.14.460241
Open publication

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A combined human <i>in silico</i> and CRISPR/Cas9-mediated <i>in vivo</i> zebrafish based approach for supporting gene target validation in early drug discoveryDOI 10.1101/2021.09.14.460241
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