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Article

Transcriptional linkage analysis with in vivo AAV-Perturb-seq.

Nature - 1 Oct 2023

Santinha Antonio J, Klingler Esther, Kuhn Maria, Farouni Rick, Lagler Sandra, Kalamakis Georgios, Lischetti Ulrike, Jabaudon Denis, Platt Randall J

Abstract excerpt

The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study genotype-phenotype relationships in complex tissues in a high-throughput manner1,2. Here we introduce adeno-associated virus (AAV)-mediated direct in vivo single-cell CRISPR screening, termed AAV-Perturb-seq, a tuneable and broadly applicable method for transcriptional linkage analysis as well as...

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Identifiers

PMID: 37730998
DOI: 10.1038/s41586-023-06570-y
PMCID: PMC10567566

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