Article

The JAK2-STAT pathway epigenetically regulates tolerized genes during the first encounter with bacterial antigens

2020-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Microbial challenges, such as widespread bacterial infection, induce endotoxin tolerance. This state of hyporesponsiveness to subsequent infections is mainly displayed by monocytes and macrophages. Endotoxin tolerance is generally acquired following a septic episode. In this study, we investigated DNA methylation changes during the acquisition of in vitro tolerance. We identified a set of TET2-...

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Literature Corpus work: 6f86a605-4990-5287-b46b-a34eb470707b
DOI: 10.1101/2020.10.16.342717

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