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Article

Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis.

Genome medicine - 29 Oct 2019

Lorente-Sorolla Clara, Garcia-Gomez Antonio, Català-Moll Francesc, Toledano Víctor, Ciudad Laura, Avendaño-Ortiz José, Maroun-Eid Charbel, Martín-Quirós Alejandro, Martínez-Gallo Mónica, Ruiz-Sanmartín Adolfo, Del Campo Álvaro García, Ferrer-Roca Ricard, Ruiz-Rodriguez Juan Carlos, Álvarez-Errico Damiana, López-Collazo Eduardo, Ballestar Esteban

Abstract excerpt

BACKGROUND: Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known to involve epigenetic and transcriptional dysregulation. METHODS: Bead arrays were used to compare global DNA methylation changes in patients with sepsis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31665078
DOI: 10.1186/s13073-019-0674-2
PMCID: PMC6820973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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