Article

Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease

2006-06-01

Abstract excerpt

Many host cell types, including endothelial and epithelial cells, neutrophils, monocytes, natural killer cells, dendritic cells and macrophages, initiate the first line of defense against infection by sensing conserved microbial structures through Toll-like receptors (TLRs). Recognition of microbial ligands by TLRs induces their oligomerization and triggers intracellular signaling pathways, leading to production o...

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Literature Corpus work: 87b9a610-f109-59fd-87e4-885027a2486e
DOI: 10.1177/09680519060120030201

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