Article

What does heritability of Alzheimer’s disease represent?

2022-09-08

Abstract excerpt

<h4>INTRODUCTION</h4> Both Alzheimer’s disease (AD) and ageing have a strong genetic component. In each case, many associated variants have been discovered, but how much missing heritability remains to be discovered is debated. Variability in the estimation of SNP-based heritability could explain the differences in reported heritability. <h4>METHODS</h4> We compute heritability in five large independent cohorts...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f6223f3-e356-5ed6-b232-e38306aa83f1
DOI: 10.1101/2022.09.07.506912

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

What does heritability of Alzheimer’s disease represent?DOI 10.1101/2022.09.07.506912Read

What does heritability of Alzheimer's disease represent?Semantic proximity Read

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review.Semantic proximity Read

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic reviewSemantic proximity Read

Genomic analyses reveal new insights into Alzheimer's diseaseSemantic proximity Read

Genetics of Alzheimer's disease: where we are, and where we are going.Semantic proximity Read

Microglia-specific polygenic risk stratification reveals distinct pathological subtypes in Alzheimer’s diseaseSemantic proximity Read

Heritability in frontotemporal dementia: more missing pieces?Semantic proximity Read

Step by step: towards a better understanding of the genetic architecture of Alzheimer’s diseaseSemantic proximity Read

Largest GWAS (N=1,126,563) of Alzheimer’s Disease Implicates Microglia and Immune CellsSemantic proximity Read

Alzheimer's disease: analyzing the missing heritability.Semantic proximity Read

Genetic variation associated with human longevity and Alzheimer’s disease risk act through microglia and oligodendrocyte cross-talkSemantic proximity Read

Genetic variation associated with human longevity and Alzheimer's disease risk act through microglia and oligodendrocyte cross-talkSemantic proximity Read