Article
Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review.
PLoS genetics - 1 Sept 2025
Liu Shiying, Bush William S, Akinyemi Rufus O, Byrd Goldie S, Caban-Holt Allison Mercedes, Rajabli Farid, Reitz Christiane, Kunkle Brian W, Tosto Giuseppe, Vance Jeffery M, Pericak-Vance Margaret, Haines Jonathan L, Williams Scott M, Crawford Dana C
Abstract excerpt
Estimating heritability has been fundamental in understanding the genetic contributions to complex disorders like late-onset Alzheimer's disease (LOAD) and provides a rationale for identifying genetic factors associated with disease susceptibility. While numerous studies have established substantial genetic contribution for LOAD, the interpretation of heritability estimates remains challenging. These challenges...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.