Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What does heritability of Alzheimer's disease represent?

PloS one - 1 Jan 2023

Baker Emily, Leonenko Ganna, Schmidt Karl Michael, Hill Matthew, Myers Amanda J, Shoai Maryam, de Rojas Itziar, Tesi Niccoló, Holstege Henne, van der Flier Wiesje M, Pijnenburg Yolande A L, Ruiz Agustin, Hardy John, van der Lee Sven, Escott-Price Valentina

Abstract excerpt

INTRODUCTION: Both late-onset Alzheimer's disease (AD) and ageing have a strong genetic component. In each case, many associated variants have been discovered, but how much missing heritability remains to be discovered is debated. Variability in the estimation of SNP-based heritability could explain the differences in reported heritability. METHODS: We compute heritability in five large independent cohorts (N =...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Alzheimer's disease research and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Genetic Associations and Epidemiology

Share to Genetic Loci

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 37115753
DOI: 10.1371/journal.pone.0281440
PMCID: PMC10146480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What does heritability of Alzheimer's disease represent?PMID 37115753Read ↗

What does heritability of Alzheimer’s disease represent?Semantic proximity Read ↗

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review.Semantic proximity Read ↗

Genomic analyses reveal new insights into Alzheimer's diseaseSemantic proximity Read ↗

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic reviewSemantic proximity Read ↗

Genetics of Alzheimer's disease: where we are, and where we are going.Semantic proximity Read ↗

Alzheimer's disease: analyzing the missing heritability.Semantic proximity Read ↗

Step by step: towards a better understanding of the genetic architecture of Alzheimer’s diseaseSemantic proximity Read ↗

Microglia-specific polygenic risk stratification reveals distinct pathological subtypes in Alzheimer’s diseaseSemantic proximity Read ↗

Largest GWAS (N=1,126,563) of Alzheimer’s Disease Implicates Microglia and Immune CellsSemantic proximity Read ↗

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s diseaseSemantic proximity Read ↗

Heritability in frontotemporal dementia: more missing pieces?Semantic proximity Read ↗

Genome-wide association studies for Alzheimer’s disease: bigger is not always betterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.