Article

Mutated clones driving leukemic transformation are already detectable at the single cell level in CD34-positive cells in the chronic phase of primary myelofibrosis

2020-12-07

Abstract excerpt

<h4>ABSTRACT</h4> Disease progression of myeloproliferative neoplasms is the result of increased genomic complexity. Since the ability to predict disease evolution is crucial for clinical decision, we studied single cell genomics and transcriptomics of CD34-positive cells from a primary myelofibrosis (PMF) patient who progressed to acute myeloid Leukemia (AML) while receiving Ruxolitinib. Single cell genomics all...

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Literature Corpus work: 6f0911b6-a82f-5334-95b3-bc7e58126ca8
DOI: 10.1101/2020.12.07.414177

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