Article

Minimal twister sister (TS)-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning

2024-07-11

Abstract excerpt

<title>Abstract</title> <p>Despite their importance in a wide range of living organisms, self-cleaving ribozymes in the human genome are few and poorly studied. Here, we performed deep mutational scanning and covariance analysis of two previously proposed self-cleaving ribozymes (LINE-1 and OR4K15). We found that the regions essential for ribozyme activities are made of two short segments, with a total of 35 and...

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Literature Corpus work: 6ef5708a-08b8-5815-9bc2-2d9a3793a9bd
DOI: 10.21203/rs.3.rs-2567304/v3

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