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Article

Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.

Nature chemical biology - 1 Sept 2016

Ren Aiming, Vušurović Nikola, Gebetsberger Jennifer, Gao Pu, Juen Michael, Kreutz Christoph, Micura Ronald, Patel Dinshaw J

Abstract excerpt

The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent discovery of the twister, twister-sister, pistol and hatchet ribozymes. We report the crystal structure of a pistol ribozyme termed env25, which adopts a compact tertiary architecture stabilized by an embedded pseudoknot fold. The G-U cleavage site adopts a splayed-apart conformation with in-line alignment of the modeled...

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Identifiers

PMID: 27398999
DOI: 10.1038/nchembio.2125
PMCID: PMC4990474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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