Resurrecting self-cleaving mini-ribozymes from 40-million-year-old LINE-1 elements in human genome

Abstract excerpt

Long Interspersed Nuclear Element (LINE) retrotransposons play an important role in genomic innovation as well as genomic instability in many eukaryotes including human. Random insertions and extinction through mutational inactivation make them perfectly time-stamped “DNA fossils”. Here, we investigated the origin of a self-cleaving ribozyme in 5’ UTR of LINE-1. We showed that this ribozyme only requires 35 nucleo...

Topics

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• Genetic Diseases, Inborn
• Genetic Variation
• Genome
• Genome, Human
• Long Interspersed Nucleotide Elements
• Mutation
• Nucleic Acid Conformation
• RNA, Catalytic

Identifiers and source

Literature Corpus work

a075dce3-0191-5a61-be75-7de666be67ec

DOI

10.1101/2021.04.06.438727