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Article

Minimal twister sister-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning.

eLife - 5 Dec 2024

Zhang Zhe, Hong Xu, Xiong Peng, Wang Junfeng, Zhou Yaoqi, Zhan Jian

Abstract excerpt

Despite their importance in a wide range of living organisms, self-cleaving ribozymes in the human genome are few and poorly studied. Here, we performed deep mutational scanning and covariance analysis of two previously proposed self-cleaving ribozymes (LINE-1 and OR4K15). We found that the regions essential for ribozyme activities are made of two short segments, with a total of 35 and 31 nucleotides only. The...

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PMID: 39636683
DOI: 10.7554/eLife.90254
PMCID: PMC11620745

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