Article

Single chromosome gains can function as metastasis suppressors and metastasis promoters in colon cancer

2019-03-27

Abstract excerpt

Most human tumors display chromosome-scale copy number alterations, and high levels of aneuploidy are frequently associated with advanced disease and poor patient prognosis. To examine the relationship between aneuploidy and cancer progression, we generated and analyzed a series of congenic human cell lines that harbor single extra chromosomes. We find that different aneuploidies can have distinct effects on invas...

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Literature Corpus work: 6ed5c2d7-0180-5247-b039-cdada71c958f
DOI: 10.1101/590547

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