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Article

Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoids

10 Jul 2024

Abstract excerpt

Aneuploidy is nearly ubiquitous in tumor genomes, but the role of aneuploidy in the early stages of cancer evolution remains unclear. Here, by inducing heterogeneous aneuploidy in non-transformed human colon organoids (colonoids), we investigated how the effects of aneuploidy on cell growth and differentiation may promote malignant transformation. Previous work implicated p53 activation as a downstream response...

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PMID: 38985518
DOI: 10.1091/mbc.e24-04-0166

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