Article

N1-Methylpseudouridine Directly Modulates Translation Dynamics

2025-10-24

Abstract excerpt

<title>Abstract</title> <p>The remarkable effectiveness of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted synthetic mRNA as a promising technology. A critical feature of this approach is the incorporation of the modified ribonucleotide N1-methylpseudouridine (m¹Ψ), which enhances antigen expression while reducing immunogenicity. However, a comprehensive understa...

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Literature Corpus work: 6ecade39-22dd-591d-805f-6b1041df0c64
DOI: 10.21203/rs.3.rs-5873147/v1

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