Article

The N-Terminal and Central Domains of CoV-2 nsp1 Play Key Functional Roles in Suppression of Cellular Gene Expression and Preservation of Viral Gene Expression

2021-06-15

Abstract excerpt

Nonstructural protein 1 (nsp1) is the first viral protein synthesized during coronavirus (CoV) infection and is a key virulence factor that dampens the innate immune response. It restricts cellular gene expression through a combination of inhibiting translation by blocking the mRNA entry channel of the 40S ribosomal subunit and by promoting mRNA degradation. We performed a detailed structure-guided mutational anal...

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Literature Corpus work: b40f433e-de67-53b2-a887-8c29befc8a6a
DOI: 10.2139/ssrn.3867728

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